Combination dutasteride plus tamsulosin significantly improves symptom scores in men with IPSS =12, PSA =1.5-10 ng/ml, prostate volume =30 ml, flow rate 5-15 ml/sec (combAT)

Combination dutasteride plus tamsulosin significantly improves symptom scores in men with IPSS =12, PSA =1.5-10 ng/ml, prostate volume =30 ml, flow rate 5-15 ml/sec (combAT)

This study was different to MTOPS because it assessed only patients with a very high risk of BPH progression (prostate volume > 30 ml and/or PSA >1.5-10 ng/ml, a minimum IPSS 12, flow rate 5-15 ml/sec) rather than all comers, and it used the more potent dual 5 alpha reductase inhibitor dutasteride 0.5 mg daily rather than the type 2 selective inhibitor finasteride in combination with tamsulosin 0.4 mg daily a selective alpha blocker. 4844 men were >50 years with no previous prostate surgery. AT mean follow up 24 months the result were:

  • Decreases in IPSS by – 6 points combination, 5 dutasteride, 4 tamsulosin
  • Improved flow rate by – 2.4 ml/sec combination, 1.9 dutasteride, 0.9 tamsulosin
  • Prostate volume reduced – 27% combination, 29% dutasteride, 0 tamsulosin
  • PSA reduced – 50% combination and dutasteride
  • 5% withdrawal from side effects erectile dysfunction, retrograde ejaculation, decreased libido, ejaculation failure, decreased semen volume, nipple pain, no floppy iris syndrome, no breast cancer.
Back to Benign Prostatic Hypertrophy (BPH)

Start typing and press Enter to search