Surgical removal of the primary kidney cancer in metastatic disease in association with cytokine treatment improves overall survival by 10 months

Surgical removal of the primary kidney cancer in metastatic disease in association with cytokine treatment improves overall survival by 10 months

In this landmark study 85 patients with metastatic kidney cancer were randomized to either surgical removal of the kidney cancer plus IFN (2-4 weeks after surgery, for a median duration of 16 weeks) or IFN alone. In the surgery group the time to progression was longer, 5 v 3 months and the overall survival was longer, 17 v 7 months. We are not sure why removing the primary tumor results in better outcomes but possibilities are removing the main source of cancer cells, reduced bleeding and pain from the tumor, improved patient immune status, improved activity of the cytokine therapy.

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